Over the past decades
remarkable progress has been made in understanding the genetic and
molecular causes of cancer. Despite this success, many fundamental
biological questions remain unsolved. For example, how cancer genes
and proteins involved in cancer susceptibility or tumorigenesis are
coordinated is unknown. In addition to studying cancer genes or proteins
individually, it is also important to understand how these elements
function together and how the cellular networks in which they operate
are affected by or contribute to cellular transformation. To address
this question, our laboratory is pursuing an interdisciplinary approach
in which experimental data are generated in situ, combined with published
functional genomic and proteomic information, and modeled to help
us understand the organization and dynamics of cancer cellular networks.
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