Choose a Research Group Colorectal and Testicular Germ Cell Tumors Cancer Gene and Viral Therapy Breast Cancer Biomarkers Radiobiology Angiogenesis Hereditary Colorectal Cancer HCC Molecular Diagnostics Cancer Risk Assessment Genetic Instability and Cancer Alloreactivity Cancer Systems Biology Human Papilloma Virus Neurofibromatosis     Presentation Lab Members Publications Collaborations and Relevant Links

Hereditary Colorectal Cancer – Familial Adenomatous Polyposis and Hereditary Non Polyposis Colorectal Cancer – is one the most common hereditary syndromes. Our group aims to gain insight in its molecular basis. We explore the functional relevance of several missense mutations in the Adenomatous Polyposis Coli (APC) gene and their contribution not only to hereditary colorectal cancer but to sporadic cancer as well. We complement this approach with the molecular analyses of FAP tumors mainly evaluating the WNT pathway and the molecular mechanisms inducing chromosomal instability in the earliest stages of colorectal tumor progression. We also study the relative contribution of differences of expression at the mRNA and protein level to FAP development. In collaboration with Genetic Counselling Unit and Molecular Diagnostics group we want to evaluate the effectiveness of molecular strategies in selecting those patients candidates for MMR gene mutation analyses. Finally we also evaluate the expression profiles of colorectal tumors, both benign and malignant, in order to identify novel prognostic marker.